The partnership aims to provide work opportunities for 500 people from these backgrounds, with plans to roll out successful initiatives nationally.
UKSE has partnered with YMCA North Staffordshire to fund employability bursaries supporting under-25s with the practical costs of securing work.
The University of Wolverhampton, Birmingham City University and Coventry University will run an event focused on digital adoption, cyber resilience and leadership skills for local small and medium-sized businesses.
Claire Ward, said: “This programme is about more than skills – it’s about confidence, resilience and belonging.”
The scheme aims to help local people use AI in daily life and work, as well as prepare thousands for jobs in technology.
Chris Burden said: “Too many young people in the West Midlands are missing out on workplace experiences because there aren’t enough being offered."
Mark Wild said: “HS2 is creating new opportunities for people now, and that will continue in the years ahead.”
Richard Parker said: “When people feel well and supported, they thrive. That’s why I'm encouraging more local employers to sign up for Thrive at Work."
The West Midlands site will be its second UK facility, backing hundreds of construction jobs and providing long-term skilled roles.
The apprenticeship levy transfer fund has helped over 2,500 SMEs with money pledged from larger companies.
The funding will initially assist up to 1,400 individuals in the West Midlands aged 18 to 24 with health conditions in securing jobs.
Citizen Housing’s gas engineers, electricians, construction workers and admin staff will begin strike action over pay this month.